A role for CD95 ligand in preventing graft rejection
Donald Bellgrau, Daniel Gold, Helena Selawry, Jodene Moore, Alex Franzusoff, Richard C. Duke
Full text: http://dx.doi.org/10.1038/377630a0
Ratings & reviews
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As reported in [1, 2], the results of this paper could not be reproduced. David Vaux, one of the reviewers of this paper, and co-author of [1], subsequently retracted the News and Views paper in Nature where he introduced the paper by Bellgrau et al. See also the post by David Vaux on Retraction Watch about this paper.
[1] Allison, J., Georgiou, H. M., Strasser, A., & Vaux, D. L. (1997). Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proceedings of the National Academy of Sciences, 94(8), 3943–3947.
[2] Kang, S. - M., Schneider, D. B., Lin, Z., Hanahan, D., Dichek, D. A., Stock, P. G., & Baekkeskov, S. (1997). Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nature Medicine, 3(7), 738–743. doi:10.1038/nm0797-738
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