Menopause Rodent Models: Suitability for Cognitive Aging Research

, , , , , ,

International Medical Journal, 26(6), 450-452 (2019) .


Abstract

Background: Recently published findings noted that women suffer from Alzheimer disease, a form of neurodegenerative disorder, more often than men, even accounting for the fact that women on average live longer. Objective: Menopause rodent model may be an invaluable tool for assessing longitudinal effects of hormones and aging, as well as providing access to body tissues especially brain, from which insight into the mechanisms related to cognitive aging and Alzheimer disease can be gleaned. Method: This review highlights the suitability and limitations of using menopause rodent models for cognitive aging research. Conclusion: Intact aging and OVX animals mimic natural and surgical menopause, respectively, hence making them suitable menopause models for cognitive aging research after taking into account their limitations.



Add your rating and review

If all scientific publications that you have read were ranked according to their scientific quality and importance from 0% (worst) to 100% (best), where would you place this publication? Please rate by selecting a range.


0% - 100%

This publication ranks between % and % of publications that I have read in terms of scientific quality and importance.


Keep my rating and review anonymous
Show publicly that I gave the rating and I wrote the review