N1-dansyl-spermine: a potent polyamine antagonist.

Brian P Kirby, Sheila A Ryder, Nikolaus Seiler, Jacques Renault, Graham G Shaw

Full text: http://dx.doi.org/10.1016/j.brainres.2004.02.075

Find on Google Scholar

---

Abstract

The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2-10 microg, i.c.v.) with spermine (100 microg, i.c.v.) resulted in a dose-dependent antagonism of the spermine-induced CNS excitation (body tremor and fatal tonic convulsions). In addition, the same dose of N1-dansyl-spermine antagonised spermine's enhancement of NMDA-induced convulsions. These results suggest that N1-dansyl-spermine is in vivo a potent antagonist of the CNS effects of spermine and of its action at the positive polyamine modulatory site on the NMDA receptor.

---

---