Role of Antioxidants in Hypoxia-induced Learning and Memory Deficit
Entesar Yaseen Abdo Qaid, Rahimah Zakaria, Shaida Fariza Sulaiman, Nurul Aiman Mohd Yusof, Nazlahshaniza Shafin, Zahiruddin Othman, Asma Hayati Ahmad, Badriya Al-Rahbi
Background: Search for natural antioxidants to ameliorate hypoxia-induced cognitive dysfunctions has attracted great interest in recent years.
Objective: This paper aimed to review published original articles on the efficacy of natural antioxidant compounds that could protect neuronal morphology and cognitive function following hypoxia exposure.
Method: A narrative literature review was undertaken. This review provides evidence from animal studies that highlight common natural antioxidants that have been used in adult animal experiments to ameliorate the cognitive impairment caused by environmental hypoxia.
Conclusion: Natural antioxidant compounds show promise of conferring neuroprotection and preserving cognitive function following hypoxia exposure and warrants further exploration